The CD5 antigen is a single-chain transmembrane glycoprotein with a molecular weight of 67 kDa. The extracellular domain consists of 3 scavenger receptor cysteine-rich (SRCR) domains of approximately 100 amino acids each. CD5 is found on all mature T lymphocytes and on most thymocytes. CD5 is also present on a B lymphocyte subset but is not found on granulocytes or monocytes. CD5 is a ligand for the CD72 antigen, which is present on B lymphocytes. The CD5+ B lymphocyte subset (knowm as B-1a lymphocytes) may arise from a non-conventional B lineage (independent of bone marrow).
NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
IVD: In Vitro Diagnostic Products. These
products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents
are labeled "Analyte Specific Reagents. Analytical and performance
characteristics are not established."
CE: CE-marked products. CE-marked products are
labeled for in vitro diagnostic use and can be traded throughout the EU.
RUO: Research Use Only Reagents. These reagents
are labeled "For Research Use Only. Not for use in diagnostic
LUO: Laboratory Use Only Reagents. These
reagents are labeled "For Laboratory Use Only."
IVD & CE: In Vitro Diagnostic Products and
CE-Marked Products. These reagents comply with the IVD and CE
classifications and are distributed worldwide for in vitro diagnostic
ASR & RUO: Analyte Specific Reagents & Research
Use Only Reagents. These reagents are labeled ASR for distribution
throughout the Americas and RUO throughout the rest of the world. These
products comply with the ASR and RUO definitions above.