The CD57 antigen (HNK-1 antigen carbohydrate moiety) is an oligosaccharide with sulfated glucoronic acid residues that may be linked to a variety of polypeptides or lipids. In peripheral blood, it is found on a subset of cells with natural killer activity. It is confined to mononuclear cells, primarily large granular lymphocytes. Many of these CD57+ cells co-express the CD8 antigen and are a subset of the suppressor / cytotoxic T lymphocytes. Cord blood T cells or NK cells lack the CD57 antigen. It is not expressed on red blood cells or on platelets but is present on some neuroectodermal tissues.
NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
IVD: In Vitro Diagnostic Products. These
products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents
are labeled "Analyte Specific Reagents. Analytical and performance
characteristics are not established."
CE: CE-marked products. CE-marked products are
labeled for in vitro diagnostic use and can be traded throughout the EU.
RUO: Research Use Only Reagents. These reagents
are labeled "For Research Use Only. Not for use in diagnostic
LUO: Laboratory Use Only Reagents. These
reagents are labeled "For Laboratory Use Only."
IVD & CE: In Vitro Diagnostic Products and
CE-Marked Products. These reagents comply with the IVD and CE
classifications and are distributed worldwide for in vitro diagnostic
ASR & RUO: Analyte Specific Reagents & Research
Use Only Reagents. These reagents are labeled ASR for distribution
throughout the Americas and RUO throughout the rest of the world. These
products comply with the ASR and RUO definitions above.