The CD45 molecules are single chain integral membrane proteins, comprising at least 5 isoforms, ranging from 180 to 220 kDa. They are generated by alternative splicing combinations of three exons (A, B, and C) of the genomic sequence. The non-restricted CD45 antigen, Leucocyte Common Antigen (LCA) consists of an extracellular sequence, proximal to the membrane, which is common to all CD45 isoforms. All the monoclonal antibodies that belong to the CD45 cluster react with this part of the antigen and are able to recognize all CD45 isoforms. These isoforms have extracytoplasmic sequences ranging from 391 to 552 amino acids long, with numerous N-linked carbohydrate attachment sites. The cytoplasmic portion contains two phospho-tyrosine-phosphatase domains. The non-restricted CD45 epitope is present on the surface of all human leucocytes; lymphocytes, eosinophils monocytes, basophils and neutrophils, by order of decreasing level of expression. CD45 is a major component of the lymphocyte membrane. It is absent from erythrocytes and platelets. It is lost during maturation of erythroid cells in the bone marrow CD45 antibodies react with leucocyte progenitors in bone marrow.
NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
IVD: In Vitro Diagnostic Products. These
products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents
are labeled "Analyte Specific Reagents. Analytical and performance
characteristics are not established."
CE: CE-marked products. CE-marked products are
labeled for in vitro diagnostic use and can be traded throughout the EU.
RUO: Research Use Only Reagents. These reagents
are labeled "For Research Use Only. Not for use in diagnostic
LUO: Laboratory Use Only Reagents. These
reagents are labeled "For Laboratory Use Only."
IVD & CE: In Vitro Diagnostic Products and
CE-Marked Products. These reagents comply with the IVD and CE
classifications and are distributed worldwide for in vitro diagnostic
ASR & RUO: Analyte Specific Reagents & Research
Use Only Reagents. These reagents are labeled ASR for distribution
throughout the Americas and RUO throughout the rest of the world. These
products comply with the ASR and RUO definitions above.